Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects

Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects

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Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.5.3.3. 11C-Methylation of precursor. The conditions under which the precursor is methylated depend critically on the class of compound of interest and ... The PLC controls the sequence of operations for the multi-port valves necessary to accomplish these steps. ... For gas handling the two- and three-port stainless steel valves are by Skinner [Honeywell Lucifer, part nos B2RX 127 DC-2 and B14 DK 1075anbsp;...

Title:Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects
Author: G. Stöcklin, V.W. Pike
Publisher:Springer Science & Business Media - 1993-06-30

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